Assimilation des données SMOS dans un modèle des surfaces continentales : mise en œuvre et évaluation sur la France

Assimiler l'humidité superficielle du sol (SSM) dans un modèle de surface améliore la modélisation du contenu en eau du sol. La télédétection est un outils indispensable pour suivre l'évolution de cette variable. SMOS, lancé en Novembre 2009, est le premier satellite dédié à l'étude de l'humidité du sol. Les premières données SMOS ont été comparées aux données ASCAT sur la France. Les données ASCAT se corrèlent mieux aux observations in situ et aux SSM simulées que les données SMOS pendant l'année 2010. Sur le sol nu du site de SMOSREX (2003-2005), les SSM mesurés ont été assimilées dans une nouvelle version multi-couches du modèle Interaction entre le Sol, la Biosphère et l'Atmosphère (ISBA). Un Filtre de Kalman Etendu Simplifié (SEKF) a été utilisé pour analyser le profil d'eau du sol dans les 11 couches de la version multi-couches du modèle de surface (ISBA-DF). Pendant les périodes sèches, les corrections impactent les 15 premiers centimètres du sol alors que pendant les périodes humides, des corrections moins intenses affectent l'ensemble de la colonne de sol. Afin de préparer l'assimilation des températures de brillance (TB), des TB ont été simulées par couplage entre ISBA-DF et un modèle d'émission micro-ondes (CMEM). Avec ISBA-DF, il est préférable de modéliser les TB en utilisant l'approche de Wilheit pour le calcul de l'émissivité de surface lisse et de prendre en compte l'impact des variations de SSM dans le calcul de la rugosité. Finalement, les TB de SMOSREX ont été assimilées dans ISBA-DF. Considérer CMEM comme opérateur d'observations dans le SEKF permet d'obtenir un état analysé proche de celui obtenu lors de l'assimilation des SSM dans ISBA-DF.Assimilating surface soil moisture (SSM) in a land surface model permits a better monitoring of the soil water content. Remote sensing is an indispensable tool for monitoring the evolution of SSM, both spatially and temporally. SMOS was launched in November 2009 and it is the first satellite specifically dedicated to SSM mapping over continents. A comparison of the first SMOS data with ASCAT over France showed that the ASCAT product was better correlated with in situ SSM observations and with SSM simulations for the year 2010. Over bare soil plot of SMOSREX (2003-2005), in situ SSM were assimilated into a new multi-layer version of the soil module of the Interaction between the Soil, Biosphere, Atmosphere (ISBA) land surface model. A simplified Extended Kalman Filter was used to analyze 11 soil layers of the ISBA multi-layer version (ISBA-DF). For dry periods, corrections affected a shallow 0-15 cm top soil layer. For wet period, weaker corrections were applied for the entire column. To prepare the assimilation of the TB, the TB were produced by coupling ISBA-DF with a microwave emission model (CMEM). With ISBA-DF, computing TB using the Wilheit smooth surface emissivity and taking into account an impact of SSM on soil roughness is recommended. Finally, the SMOSREX TB observations were assimilated by ISBA-DF. Considering CMEM as an observation operator provided a SSM and total soil water content analysis similar to the analysis obtained by assimilating direct SSM observations in ISBA-DF

J Thromb Haemost

Essentials To reliably study the respective roles of blood and endothelial cells in hemostasis, mouse models with a strong and specific endothelial expression of the Cre recombinase are needed. Using mT/mG reporter mice and conditional JAK2 mice, we compared Pdgfb-iCreERT2 and Cdh5(PAC)-CreERT2 with well-characterized Tie2-Cre mice. Comparison of recombination efficiency and specificity towards blood lineage reveals major differences between endothelial transgenic mice. Cre-mediated recombination occurs in a small number of adult hematopoietic stem cells in Pdgfb-iCreERT2;JAK2 transgenic mice. SUMMARY: Background The vessel wall, and particularly blood endothelial cells (BECs), are intensively studied to better understand hemostasis and target thrombosis. To understand the specific role of BECs, it is important to have mouse models that allow specific and homogeneous expression of genes of interest in all BEC beds without concomitant expression in blood cells. Inducible Pdgfb-iCreERT2 and Cdh5(PAC)-CreERT2 transgenic mice are widely used for BEC targeting. However, issues remain in terms of recombination efficiency and specificity regarding hematopoietic cells. Objectives To determine which mouse model to choose when strong expression of a transgene is required in adult BECs from various organs, without concomitant expression in hematopoietic cells. Methods Using mT/mG reporter mice to measure recombination efficiency and conditional JAK2 mice to assess specificity regarding hematopoietic cells, we compared Pdgfb-iCreERT2 and Cdh5(PAC)-CreERT2 with well-characterized Tie2-Cre mice. Results Adult Cdh5(PAC)-CreERT2 mice are endothelial specific but require a dose of 10 mg of tamoxifen to allow constant Cre expression. Pdgfb-iCreERT2 mice injected with 5 mg of tamoxifen are appropriate for most endothelial research fields except liver studies, as hepatic sinusoid ECs are not recombined. Surprisingly, 2 months after induction of Cre-mediated recombination, all Pdgfb-iCreERT2;JAK2 mice developed a myeloproliferative neoplasm that is related to the presence of JAK2V617F in hematopoietic cells, showing for the first time that Cre-mediated recombination occurs in a small number of adult hematopoietic stem cells in Pdgfb-iCreERT2 transgenic mice. Conclusion This study provides useful guidelines for choosing the best mouse line to study the role of BECs in hemostasis and thrombosis

The Genetic Basis of Hepatosplenic T-cell Lymphoma

Hepatosplenic T cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy number alterations in the disease. Chromatin modifying genes including SETD2, INO80 and ARID1B were commonly mutated in HSTL, affecting 62% of cases. HSTLs manifest frequent mutations in STAT5B (31%), STAT3 (9%), and PIK3CD (9%) for which there currently exist potential targeted therapies. In addition, we noted less frequent events in EZH2, KRAS and TP53. SETD2 was the most frequently silenced gene in HSTL. We experimentally demonstrated that SETD2 acts as a tumor suppressor gene. In addition, we found that mutations in STAT5B and PIK3CD activate critical signaling pathways important to cell survival in HSTL. Our work thus defines the genetic landscape of HSTL and implicates novel gene mutations linked to HSTL pathogenesis and potential treatment targets

Correction. "The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms" Leukemia. 2022 Jul;36(7):1720-1748

We herein present an overview of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Besides listing the entities of the classification, we highlight and explain changes from the revised 4th edition. These include reorganization of entities by a hierarchical system as is adopted throughout the 5th edition of the WHO classification of tumours of all organ systems, modification of nomenclature for some entities, revision of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities, as well as inclusion of tumour-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms

Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France

The term “gray-zone” lymphoma has been used to denote a group of lymphomas with overlapping histological, biological, and clinical features between various types of lymphomas. It has been used in the context of Hodgkin lymphomas (HL) and non-Hodgkin lymphomas (NHL), including classical HL (CHL), and primary mediastinal large B cell lymphoma, cases with overlapping features between nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B cell lymphoma, CHL, and Epstein–Barr-virus-positive lymphoproliferative disorders, and peripheral T cell lymphomas simulating CHL. A second group of gray-zone lymphomas includes B cell NHL with intermediate features between diffuse large B cell lymphoma and classical Burkitt lymphoma. In order to review controversial issues in gray-zone lymphomas, a joint Workshop of the European Association for Hematopathology and the Society for Hematopathology was held in Bordeaux, France, in September 2008. The panel members reviewed and discussed 145 submitted cases and reached consensus diagnoses. This Workshop summary is focused on the most controversial aspects of gray-zone lymphomas and describes the panel’s proposals regarding diagnostic criteria, terminology, and new prognostic and diagnostic parameters

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Atlas de pathologie splénique

BORDEAUX2-BU Santé (330632101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

SWAF-HR: A high spatial and temporal resolution water surface extent product over the amazon basin

International audienceWetlands and open waters are key components of the hydrological and carbon cycles but their spatio-temporal dynamics are still not well known, mostly over tropical areas. In this paper, a new water surface product at high spatial resolution (30 arcsec) and high temporal resolution (3 days) over the Amazon basin for recent years (2010-2016) is presented. This product comes from the synergy between recent products: (1) water surface fraction at coarse spatial resolution from L-band microwave sensor (Soil Moisture and Ocean Salinity - SMOS), (2) Global Surface Water Occurrence (GSWO) from Landsat sensor and (3) the new Digital Elevation Model (DEM) Multi-Error-Removed-Improved-Terrain (MERIT) based on the Shuttle Radar Topography Mission (SRTM) observations

Assimilation of surface soil moisture into a multilayer soil model: design and evaluation at local scale

International audienceLand surface models (LSM) have improved considerably in the last two decades. In this study, the Interactions between Surface, Biosphere, and Atmosphere (ISBA) LSM soil diffusion scheme is used (with 11 soil layers represented). A simplified extended Kalman filter (SEKF) allows ground observations of surface soil moisture (SSM) to be assimilated in the multilayer LSM in order to constrain deep soil moisture. In parallel, the same simulations are performed using the ISBA LSM with 2 soil layers (a thin surface layer and a bulk reservoir). Simulations are performed over a 3 yr period (2003–2005) for a bare soil field in southwestern France, at the SMOSREX (Surface Monitoring Of the Soil Reservoir Experiment) site. Analyzed soil moisture values correlate better with soil moisture observations when the ISBA LSM soil diffusion scheme is used. The Kalman gain is greater from the surface to 45 cm than below this limit. For dry periods, corrections introduced by the assimilation scheme mainly affect the first 15 cm of soil whereas weaker corrections impact the total soil column for wet periods. Such seasonal corrections cannot be described by the two-layer ISBA LSM. Sensitivity studies performed with the multilayer LSM show improved results when SSM (0–6 cm) is assimilated into the second layer (1–5 cm) than into the first layer (0–1 cm). The introduction of vertical correlations in the background error covariance matrix is also encouraging. Using a yearly cumulative distribution function (CDF)-matching scheme for bias correction instead of matching over the three years permits the seasonal variability of the soil moisture content to be better transcribed. An assimilation experiment has also been performed by forcing ISBA-DF (diffusion scheme) with a local forcing, setting precipitation to zero. This experiment shows the benefit of the SSM assimilation for correcting inaccurate atmospheric forcing

Global Weekly Inland Surface Water Dynamics from L-Band Microwave

International audienceWetlands and open waters are key components of the hydrological and carbon cycles but their spatio-temporal dynamics are still not well known at global scale. Current paper presents a new methodology to retrieve water fraction at coarse scale and high temporal resolution (one week) using L-Band multi-angular and dual polarisation remote sensing data from SMOS mission. The dataset labeled G-SWAF (or Global-SWAF) is an extention of the SWAF approach which did not consider the separate contributions of the Soil, Vegetation and water fractions. The comparison to existing datasets shows more water fraction detecting in Tropical areas but better consideration of high latitudes is still needed to be included in future studies. The use of such datasets with the future data from the SWOT (NASA/CNES) mission will provide global evaluation of inland open water volumes at 10 days scale